Syntaxin Opening by the MUN Domain Underlies the Function of Munc13 in Synaptic Vesicle Priming

UNC-13-Munc13s play a central function in synaptic vesicle priming through their MUN domains. However, it is unclear whether this function arises from the ability of the MUN domain to mediate the transition from the Munc18-1–closed syntaxin-1 complex to the SNARE complex in vitro. The crystal struct...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Yang, Xiaoyu, Wang, Shen, Sheng, Yi, Zhang, Mingshu, Zou, Wenjuan, Wu, Lijie, Kang, Lijun, Rizo, Josep, Zhang, Rongguang, Xu, Tao, Ma, Cong
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809529/
https://ncbi.nlm.nih.gov/pubmed/26030875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3038
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