Syntaxin Opening by the MUN Domain Underlies the Function of Munc13 in Synaptic Vesicle Priming

UNC-13-Munc13s play a central function in synaptic vesicle priming through their MUN domains. However, it is unclear whether this function arises from the ability of the MUN domain to mediate the transition from the Munc18-1–closed syntaxin-1 complex to the SNARE complex in vitro. The crystal struct...

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Détails bibliographiques
Publié dans:Nat Struct Mol Biol
Auteurs principaux: Yang, Xiaoyu, Wang, Shen, Sheng, Yi, Zhang, Mingshu, Zou, Wenjuan, Wu, Lijie, Kang, Lijun, Rizo, Josep, Zhang, Rongguang, Xu, Tao, Ma, Cong
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809529/
https://ncbi.nlm.nih.gov/pubmed/26030875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3038
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