Heterodimerization of Munc13 C(2)A domain with RIM regulates synaptic vesicle docking and priming

The presynaptic active zone protein Munc13 is essential for neurotransmitter release, playing key roles in vesicle docking and priming. Mechanistically, it is thought that the C(2)A domain of Munc13 inhibits the priming function by homodimerization, and that RIM disrupts the autoinhibitory homodimer...

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Pubblicato in:Nat Commun
Autori principali: Camacho, Marcial, Basu, Jayeeta, Trimbuch, Thorsten, Chang, Shuwen, Pulido-Lozano, Cristina, Chang, Shwu-Shin, Duluvova, Irina, Abo-Rady, Masin, Rizo, Josep, Rosenmund, Christian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436228/
https://ncbi.nlm.nih.gov/pubmed/28489077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15293
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