Heterodimerization of Munc13 C(2)A domain with RIM regulates synaptic vesicle docking and priming

The presynaptic active zone protein Munc13 is essential for neurotransmitter release, playing key roles in vesicle docking and priming. Mechanistically, it is thought that the C(2)A domain of Munc13 inhibits the priming function by homodimerization, and that RIM disrupts the autoinhibitory homodimer...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Camacho, Marcial, Basu, Jayeeta, Trimbuch, Thorsten, Chang, Shuwen, Pulido-Lozano, Cristina, Chang, Shwu-Shin, Duluvova, Irina, Abo-Rady, Masin, Rizo, Josep, Rosenmund, Christian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436228/
https://ncbi.nlm.nih.gov/pubmed/28489077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15293
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