Functional synergy between the Munc13 C-terminal C(1) and C(2) domains

Neurotransmitter release requires SNARE complexes to bring membranes together, NSF-SNAPs to recycle the SNAREs, Munc18-1 and Munc13s to orchestrate SNARE complex assembly, and Synaptotagmin-1 to trigger fast Ca(2+)-dependent membrane fusion. However, it is unclear whether Munc13s function upstream a...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Liu, Xiaoxia, Seven, Alpay Burak, Camacho, Marcial, Esser, Victoria, Xu, Junjie, Trimbuch, Thorsten, Quade, Bradley, Su, Lijing, Ma, Cong, Rosenmund, Christian, Rizo, Josep
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2016
Assuntos:
Biophysics and Structural Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4927299/
https://ncbi.nlm.nih.gov/pubmed/27213521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13696
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