Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C(1)C(2)BMUN

Munc13–1 acts as a master regulator of neurotransmitter release, mediating docking-priming of synaptic vesicles and diverse presynaptic plasticity processes. It is unclear how the functions of the multiple domains of Munc13–1 are coordinated. The crystal structure of a Munc13–1 fragment including it...

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Udgivet i:eLife
Main Authors: Xu, Junjie, Camacho, Marcial, Xu, Yibin, Esser, Victoria, Liu, Xiaoxia, Trimbuch, Thorsten, Pan, Yun-Zu, Ma, Cong, Tomchick, Diana R, Rosenmund, Christian, Rizo, Josep
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Biophysics and Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344669/
https://ncbi.nlm.nih.gov/pubmed/28177287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22567
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