Novel Very Long-Chain α-Methoxylated Δ5,9 Fatty Acids from the Sponge Asteropus niger are Effective Inhibitors of Topoisomerases IB

The novel fatty acids (2R,5Z,9Z)-2-methoxy-25-methyl-5,9-hexacosadienoic acid (1a) and (2R,5Z,9Z)-2-methoxy-24-methyl-5,9-hexacosadienoic acid (1b) were isolated in 80% purity from the Caribbean sponge Asteropus niger by chloroform/methanol extraction followed by solvent partitioning and silica gel...

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Veröffentlicht in:Lipids
Hauptverfasser: Carballeira, Néstor M., Montano, Nashbly, Amador, Luis A., Rodríguez, Abimael D., Golovko, Mikhail Y., Golovko, Svetlana A., Reguera, Rosa M., Álvarez-Velilla, Raquel, Balaña-Fouce, Rafael
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809140/
https://ncbi.nlm.nih.gov/pubmed/26694606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11745-015-4114-9
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