IL-12-conditioning improves retrovirally-mediated transduction efficiency of CD8(+) T cells

The ability to genetically modify T cells is a critical component to many immunotherapeutic strategies and research studies. However, the success of these approaches is often limited by transduction efficiency. Since retroviral vectors require cell division for integration, transduction efficiency i...

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Detalhes bibliográficos
Publicado no:Cancer Gene Ther
Main Authors: Andrijauskaite, Kristina, Suriano, Samantha, Cloud, Colleen A., Li, Mingli, Kesarwani, Pravin, Stefanik, Leah S., Moxley, Kelly M., Salem, Mohamed L, Garrett-Mayer, Elizabeth, Paulos, Chrystal M., Mehrotra, Shikhar, Kochenderfer, James N., Cole, David J., Rubinstein, Mark P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807400/
https://ncbi.nlm.nih.gov/pubmed/26182912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2015.28
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