IL-12-conditioning improves retrovirally-mediated transduction efficiency of CD8(+) T cells

The ability to genetically modify T cells is a critical component to many immunotherapeutic strategies and research studies. However, the success of these approaches is often limited by transduction efficiency. Since retroviral vectors require cell division for integration, transduction efficiency i...

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Gepubliceerd in:Cancer Gene Ther
Hoofdauteurs: Andrijauskaite, Kristina, Suriano, Samantha, Cloud, Colleen A., Li, Mingli, Kesarwani, Pravin, Stefanik, Leah S., Moxley, Kelly M., Salem, Mohamed L, Garrett-Mayer, Elizabeth, Paulos, Chrystal M., Mehrotra, Shikhar, Kochenderfer, James N., Cole, David J., Rubinstein, Mark P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807400/
https://ncbi.nlm.nih.gov/pubmed/26182912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2015.28
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