Interleukin-12 enhances the function and anti-tumor activity in murine and human CD8(+) T cells

Mouse CD8(+) T cells conditioned with interleukin (IL)-12 ex vivo mediate the potent regression of established melanoma when transferred into lymphodepleted mice. However, the quantitative and qualitative changes induced by IL-12 in the responding mouse CD8(+) T cells have not been well defined. Mor...

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Udgivet i:Cancer Immunol Immunother
Main Authors: Rubinstein, Mark P., Su, Ee Wern, Suriano, Samantha, Cloud, Colleen A., Andrijauskaite, Kristina, Kesarwani, Pravin, Schwartz, Kristina M., Williams, Katelyn M., Johnson, C. Bryce, Li, Mingli, Scurti, Gina M., Salem, Mohamed L., Paulos, Chrystal M., Garrett-Mayer, Elizabeth, Mehrotra, Shikhar, Cole, David J.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2015
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4804872/
https://ncbi.nlm.nih.gov/pubmed/25676709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-015-1655-y
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