Ex vivo IL-12-Priming during CD8(+) T Cell Activation Dramatically Improves Adoptive T Cell Transfer Anti-Tumor Efficacy in a Lymphodepleted Host

BACKGROUND: Clinical application of adoptive T cell therapy (ACT) has been hindered by an inability to generate adequate numbers of non-tolerized, functionally active tumor-specific T cells which can persist in vivo. In order to address this, we evaluated the impact of IL-12 signaling during tumor-s...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Rubinstein, Mark P, Cloud, Colleen A, Garrett, Tracy E, Moore, Caitlin J, Schwartz, Kristina M, Johnson, C Bryce, Craig, David H, Salem, Mohamed L, Paulos, Chrystal M, Cole, David J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429131/
https://ncbi.nlm.nih.gov/pubmed/22360982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jamcollsurg.2011.12.034
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge