Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ

Cone snail toxins are well known blockers of voltage-gated sodium channels, a property that is of broad interest in biology and therapeutically in treating neuropathic pain and neurological disorders. Although most conotoxin channel blockers function by direct binding to a channel and disrupting its...

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Vydáno v:J Biol Chem
Hlavní autoři: Green, Brad R., Gajewiak, Joanna, Chhabra, Sandeep, Skalicky, Jack J., Zhang, Min-Min, Rivier, Jean E., Bulaj, Grzegorz, Olivera, Baldomero M., Yoshikami, Doju, Norton, Raymond S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807300/
https://ncbi.nlm.nih.gov/pubmed/26817840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.697672
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