Ceramide Synthase 5 Is Essential to Maintain C(16:0)-Ceramide Pools and Contributes to the Development of Diet-induced Obesity

Ceramides are bioactive sphingolipids, which are composed of sphingoid bases carrying acyl chains of various lengths. Ceramides are synthesized by a family of six ceramide synthases (CerS) in mammals, which produce ceramides with different N-linked acyl chains. Increased ceramide levels are known to...

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Vydáno v:J Biol Chem
Hlavní autoři: Gosejacob, Dominic, Jäger, Philipp S., vom Dorp, Katharina, Frejno, Martin, Carstensen, Anne C., Köhnke, Monika, Degen, Joachim, Dörmann, Peter, Hoch, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Lipids
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807283/
https://ncbi.nlm.nih.gov/pubmed/26853464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.691212
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