Adult Ceramide Synthase 2 (CERS2)-deficient Mice Exhibit Myelin Sheath Defects, Cerebellar Degeneration, and Hepatocarcinomas

(Dihydro)ceramide synthase 2 (cers2, formerly called lass2) is the most abundantly expressed member of the ceramide synthase gene family, which includes six isoforms in mice. CERS2 activity has been reported to be specific toward very long fatty acid residues (C22–C24). In order to study the biologi...

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Autori principali: Imgrund, Silke, Hartmann, Dieter, Farwanah, Hany, Eckhardt, Matthias, Sandhoff, Roger, Degen, Joachim, Gieselmann, Volkmar, Sandhoff, Konrad, Willecke, Klaus
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785198/
https://ncbi.nlm.nih.gov/pubmed/19801672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.031971
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