Absence of 2-Hydroxylated Sphingolipids Is Compatible with Normal Neural Development But Causes Late-Onset Axon and Myelin Sheath Degeneration

Sphingolipids containing 2-hydroxylated fatty acids are among the most abundant lipid components of the myelin sheath and therefore are thought to play an important role in formation and function of myelin. To prove this hypothesis, we generated mice lacking a functional fatty acid 2-hydroxylase (FA...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Zöller, Inge, Meixner, Marion, Hartmann, Dieter, Büssow, Heinrich, Meyer, Rainer, Gieselmann, Volkmar, Eckhardt, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671223/
https://ncbi.nlm.nih.gov/pubmed/18815260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0458-08.2008
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