Inactivation of Ceramide Synthase 6 in Mice Results in an Altered Sphingolipid Metabolism and Behavioral Abnormalities

The N-acyl chain length of ceramides is determined by the specificity of different ceramide synthases (CerS). The CerS family in mammals consists of six members with different substrate specificities and expression patterns. We have generated and characterized a mouse line harboring an enzymatically...

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Bibliographic Details
Main Authors: Ebel, Philipp, vom Dorp, Katharina, Petrasch-Parwez, Elisabeth, Zlomuzica, Armin, Kinugawa, Kiyoka, Mariani, Jean, Minich, David, Ginkel, Christina, Welcker, Jochen, Degen, Joachim, Eckhardt, Matthias, Dere, Ekrem, Dörmann, Peter, Willecke, Klaus
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Lipids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774410/
https://ncbi.nlm.nih.gov/pubmed/23760501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.479907
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