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Clusterin Binds to Aβ(1–42) Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation

The aggregation of amyloid β protein (Aβ) is a fundamental pathogenic mechanism leading to the neuronal damage present in Alzheimer disease, and soluble Aβ oligomers are thought to be a major toxic culprit. Thus, better knowledge and specific targeting of the pathways that lead to these noxious spec...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Beeg, Marten, Stravalaci, Matteo, Romeo, Margherita, Carrá, Arianna Dorotea, Cagnotto, Alfredo, Rossi, Alessandro, Diomede, Luisa, Salmona, Mario, Gobbi, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807280/
https://ncbi.nlm.nih.gov/pubmed/26884339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.689539
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