Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis

The mTOR complex 1 (mTORC1) and endoplasmic reticulum (ER) stress pathways are critical regulators of intestinal inflammation and colon cancer growth. Sestrins are stress-inducible proteins, which suppress both mTORC1 and ER stress; however, the role of Sestrins in colon physiology and tumorigenesis...

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Enregistré dans:
Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Ro, Seung-Hyun, Xue, Xiang, Ramakrishnan, Sadeesh K, Cho, Chun-Seok, Namkoong, Sim, Jang, Insook, Semple, Ian A, Ho, Allison, Park, Hwan-Woo, Shah, Yatrik M, Lee, Jun Hee
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2016
Sujets:
Cell Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805551/
https://ncbi.nlm.nih.gov/pubmed/26913956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12204
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