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Hepatoprotective role of Sestrin2 against chronic ER stress
Upon prolonged endoplasmic reticulum (ER) stress, cells attenuate protein translation to prevent accumulation of unfolded proteins. Here we show that Sestrin2 is critical for this process. Sestrin2 expression is induced by an ER stress-activated transcription factor CCAAT-enhancer-binding protein be...
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| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4074707/ https://ncbi.nlm.nih.gov/pubmed/24947615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5233 |
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