Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species

Uncoupling protein 1 (Ucp1), which is localized in the mitochondrial inner membrane of mammalian brown adipose tissue (BAT), generates heat by uncoupling oxidative phosphorylation. Upon cold exposure or nutritional abundance, sympathetic neurons stimulate BAT to express Ucp1 to induce energy dissipa...

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Bibliografske podrobnosti
Main Authors: Ro, Seung-Hyun, Nam, Myeongjin, Jang, Insook, Park, Hwan-Woo, Park, Haeli, Semple, Ian A., Kim, Myungjin, Kim, Jeong Sig, Park, Haewon, Einat, Paz, Damari, Golda, Golikov, Maya, Feinstein, Elena, Lee, Jun Hee
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040599/
https://ncbi.nlm.nih.gov/pubmed/24825887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401787111
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