Hepatoprotective role of Sestrin2 against chronic ER stress

Upon prolonged endoplasmic reticulum (ER) stress, cells attenuate protein translation to prevent accumulation of unfolded proteins. Here we show that Sestrin2 is critical for this process. Sestrin2 expression is induced by an ER stress-activated transcription factor CCAAT-enhancer-binding protein be...

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Autori principali: Park, Hwan-Woo, Park, Haeli, Ro, Seung-Hyun, Jang, Insook, Semple, Ian A., Kim, David N., Kim, Myungjin, Nam, Myeongjin, Zhang, Deqiang, Yin, Lei, Lee, Jun Hee
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074707/
https://ncbi.nlm.nih.gov/pubmed/24947615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5233
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