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Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis
The mTOR complex 1 (mTORC1) and endoplasmic reticulum (ER) stress pathways are critical regulators of intestinal inflammation and colon cancer growth. Sestrins are stress-inducible proteins, which suppress both mTORC1 and ER stress; however, the role of Sestrins in colon physiology and tumorigenesis...
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| Veröffentlicht in: | eLife |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications, Ltd
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4805551/ https://ncbi.nlm.nih.gov/pubmed/26913956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12204 |
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