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Comparing and Combining Biomarkers as Principle Surrogates for Time-to-Event Clinical Endpoints

Principal surrogate endpoints are useful as targets for Phase I and II trials. In many recent trials, multiple post-randomization biomarkers are measured. However, few statistical methods exist for comparison of or combination of biomarkers as principal surrogates and none of these methods to our kn...

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Detalles Bibliográficos
Publicado en:Stat Med
Main Authors: Gabriel, Erin E., Sachs, Michael C., Gilbert, Peter B.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801510/
https://ncbi.nlm.nih.gov/pubmed/25352131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6349
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