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Optimizing and Evaluating Biomarker Combinations as Trial Level General Surrogates
We extend the method proposed in(1) for trial level general surrogate evaluation to allow combinations of biomarkers, and provide a procedure for finding the ‘best’ combination of biomarkers based on the absolute prediction error summary of surrogate quality. We use a non-parametric Bayesian model t...
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| Publicado en: | Stat Med |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6399061/ https://ncbi.nlm.nih.gov/pubmed/30306600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.7996 |
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