Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles

A central challenge to the development of protein-based therapeutics is the inefficiency of delivery of protein cargo across the mammalian cell membrane, including escape from endosomes. Here we report that combining bioreducible lipid nanoparticles with negatively supercharged Cre recombinase or an...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Wang, Ming, Zuris, John A., Meng, Fantao, Rees, Holly, Sun, Shuo, Deng, Pu, Han, Yong, Gao, Xue, Pouli, Dimitra, Wu, Qi, Georgakoudi, Irene, Liu, David R., Xu, Qiaobing
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2016
Предметы:
Physical Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801296/
https://ncbi.nlm.nih.gov/pubmed/26929348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520244113
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