Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing

Messenger RNA (mRNA) therapeutics have been explored to treat various genetic disorders. Lipid-derived nanomaterials are currently one of the most promising biomaterials that mediate effective mRNA delivery. However, efficiency and safety of this nanomaterial-based mRNA delivery remains a challenge...

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Dades bibliogràfiques
Publicat a:Sci Adv
Autors principals: Zhang, Xinfu, Zhao, Weiyu, Nguyen, Giang N., Zhang, Chengxiang, Zeng, Chunxi, Yan, Jingyue, Du, Shi, Hou, Xucheng, Li, Wenqing, Jiang, Justin, Deng, Binbin, McComb, David W., Dorkin, Robert, Shah, Aalok, Barrera, Luis, Gregoire, Francine, Singh, Manmohan, Chen, Delai, Sabatino, Denise E., Dong, Yizhou
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442477/
https://ncbi.nlm.nih.gov/pubmed/32937374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc2315
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