Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing

Messenger RNA (mRNA) therapeutics have been explored to treat various genetic disorders. Lipid-derived nanomaterials are currently one of the most promising biomaterials that mediate effective mRNA delivery. However, efficiency and safety of this nanomaterial-based mRNA delivery remains a challenge...

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Detalles Bibliográficos
Publicado en:Sci Adv
Main Authors: Zhang, Xinfu, Zhao, Weiyu, Nguyen, Giang N., Zhang, Chengxiang, Zeng, Chunxi, Yan, Jingyue, Du, Shi, Hou, Xucheng, Li, Wenqing, Jiang, Justin, Deng, Binbin, McComb, David W., Dorkin, Robert, Shah, Aalok, Barrera, Luis, Gregoire, Francine, Singh, Manmohan, Chen, Delai, Sabatino, Denise E., Dong, Yizhou
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442477/
https://ncbi.nlm.nih.gov/pubmed/32937374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc2315
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