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Synthetic Oligonucleotides Inhibit CRISPR-Cpf1-Mediated Genome Editing
Previously, researchers discovered a series of anti-CRISPR proteins that inhibit CRISPR-Cas activity, such as Cas9 and Cpf1 (Cas12a). Herein, we constructed crRNA variants consisting of chemically modified DNA-crRNA and RNA-crRNA duplexes and identified that phosphorothioate (PS)-modified DNA-crRNA...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6326575/ https://ncbi.nlm.nih.gov/pubmed/30566855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.11.079 |
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