Synthetic Oligonucleotides Inhibit CRISPR-Cpf1-Mediated Genome Editing

Previously, researchers discovered a series of anti-CRISPR proteins that inhibit CRISPR-Cas activity, such as Cas9 and Cpf1 (Cas12a). Herein, we constructed crRNA variants consisting of chemically modified DNA-crRNA and RNA-crRNA duplexes and identified that phosphorothioate (PS)-modified DNA-crRNA...

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Udgivet i:Cell Rep
Main Authors: Li, Bin, Zeng, Chunxi, Li, Wenqing, Zhang, Xinfu, Luo, Xiao, Zhao, Weiyu, Zhang, Chengxiang, Dong, Yizhou
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326575/
https://ncbi.nlm.nih.gov/pubmed/30566855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.11.079
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