Fast and Efficient CRISPR/Cas9 Genome Editing In Vivo Enabled by Bioreducible Lipid and Messenger RNA Nanoparticles

A main challenge to broaden the biomedical application of CRISPR/Cas9 (clustered regularly interspaced short palindromic repeat (CRISPR) associated protein 9) genome editing technique is the delivery of Cas9 nuclease and single-guide RNA (sgRNA) into the specific cell and organ. An effective and ver...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Adv Mater
Main Authors: Liu, Ji, Chang, Jin, Jiang, Ying, Meng, Xiandi, Sun, Tianmeng, Mao, Lanqun, Xu, Qiaobing, Wang, Ming
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6732788/
https://ncbi.nlm.nih.gov/pubmed/31215123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adma.201902575
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