CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy

Harnessing CRISPR-Cas9 technology for cancer therapeutics has been hampered by low editing efficiency in tumors and potential toxicity of existing delivery systems. Here, we describe a safe and efficient lipid nanoparticle (LNP) for the delivery of Cas9 mRNA and sgRNAs that use a novel amino-ionizab...

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Detalhes bibliográficos
Publicado no:Sci Adv
Principais autores: Rosenblum, Daniel, Gutkin, Anna, Kedmi, Ranit, Ramishetti, Srinivas, Veiga, Nuphar, Jacobi, Ashley M., Schubert, Mollie S., Friedmann-Morvinski, Dinorah, Cohen, Zvi R., Behlke, Mark A., Lieberman, Judy, Peer, Dan
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673804/
https://ncbi.nlm.nih.gov/pubmed/33208369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc9450
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