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Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes
Therapeutic alteration of gene expression in vivo can be achieved by delivering nucleic acids (e.g., mRNA, siRNA) using nanoparticles. Recent progress in modified messenger RNA (mmRNA) synthesis facilitated the development of lipid nanoparticles (LNPs) loaded with mmRNA as a promising tool for in vi...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6206083/ https://ncbi.nlm.nih.gov/pubmed/30374059 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06936-1 |
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