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Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes
Therapeutic alteration of gene expression in vivo can be achieved by delivering nucleic acids (e.g., mRNA, siRNA) using nanoparticles. Recent progress in modified messenger RNA (mmRNA) synthesis facilitated the development of lipid nanoparticles (LNPs) loaded with mmRNA as a promising tool for in vi...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6206083/ https://ncbi.nlm.nih.gov/pubmed/30374059 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06936-1 |
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