Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles

A central challenge to the development of protein-based therapeutics is the inefficiency of delivery of protein cargo across the mammalian cell membrane, including escape from endosomes. Here we report that combining bioreducible lipid nanoparticles with negatively supercharged Cre recombinase or an...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wang, Ming, Zuris, John A., Meng, Fantao, Rees, Holly, Sun, Shuo, Deng, Pu, Han, Yong, Gao, Xue, Pouli, Dimitra, Wu, Qi, Georgakoudi, Irene, Liu, David R., Xu, Qiaobing
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801296/
https://ncbi.nlm.nih.gov/pubmed/26929348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520244113
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