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Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles
A central challenge to the development of protein-based therapeutics is the inefficiency of delivery of protein cargo across the mammalian cell membrane, including escape from endosomes. Here we report that combining bioreducible lipid nanoparticles with negatively supercharged Cre recombinase or an...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4801296/ https://ncbi.nlm.nih.gov/pubmed/26929348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520244113 |
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