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Leukocyte integrin α(L)β(2) headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops

High-resolution crystal structures of the headpiece of lymphocyte function-associated antigen-1 (integrin α(L)β(2)) reveal how the αI domain interacts with its platform formed by the α-subunit β-propeller and β-subunit βI domains. The α(L)β(2) structures compared with α(X)β(2) structures show that t...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Sen, Mehmet, Springer, Timothy A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801256/
https://ncbi.nlm.nih.gov/pubmed/26936951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601379113
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