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Ligand- and cation-induced structural alterations of the leukocyte integrin LFA-1
In αI integrins, including leukocyte function–associated antigen 1 (LFA-1), ligand-binding function is delegated to the αI domain, requiring extra steps in the relay of signals that activate ligand binding and coordinate it with cytoplasmic signals. Crystal structures reveal great variation in orien...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5925802/ https://ncbi.nlm.nih.gov/pubmed/29507098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000710 |
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