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Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1
The activity of integrin LFA-1 (α(L)β(2)) to its ligand ICAM-1 is regulated through the conformational changes of its ligand-binding domain, the I domain of α(L) chain, from an inactive, low-affinity closed form (LA), to an intermediate-affinity form (IA), and then finally, to a high-affinity open f...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2775275/ https://ncbi.nlm.nih.gov/pubmed/19805116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909301106 |
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