AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes

Affinity of integrin lymphocyte function-associated antigen 1 (LFA-1) is enhanced by conformational changes from the low-affinity closed form to the high-affinity (HA) open form of the ligand-binding inserted (I) domain as shown by work with purified I domains. However, affinity up-regulation of LFA...

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Detalhes bibliográficos
Main Authors: Shimaoka, Motomu, Kim, Minsoo, Cohen, Edward H., Yang, Wei, Astrof, Nathan, Peer, Dan, Salas, Azucena, Ferrand, Audrey, Springer, Timothy A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1599901/
https://ncbi.nlm.nih.gov/pubmed/16963559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605716103
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