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Transition from Rolling to Firm Adhesion Can Be Mimicked by Extension of Integrin α(L)β(2) in an Intermediate Affinity State
α(L)β(2) affinity for intercellular adhesion molecule-1 (ICAM-1) is regulated by the conformation of the α(L) I domain, which is in turn controlled by the conformation and orientation of other adjacent domains. Additionally, overall integrin conformation (bent versus straightened) influences the ori...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1599852/ https://ncbi.nlm.nih.gov/pubmed/16505487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M512472200 |
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