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Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring
The function of some multidomain proteins is regulated by interdomain communication. We use second-site suppressor cysteine mutations to test a hypothesis on how the inserted (I)-like domain in the integrin β-subunit regulates ligand binding by the neighboring I domain in the integrin α-subunit [Hut...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC365718/ https://ncbi.nlm.nih.gov/pubmed/14978279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307340101 |
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