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Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring

The function of some multidomain proteins is regulated by interdomain communication. We use second-site suppressor cysteine mutations to test a hypothesis on how the inserted (I)-like domain in the integrin β-subunit regulates ligand binding by the neighboring I domain in the integrin α-subunit [Hut...

詳細記述

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書誌詳細
主要な著者: Yang, Wei, Shimaoka, Motomu, Salas, Azucena, Takagi, Junichi, Springer, Timothy A.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2004
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC365718/
https://ncbi.nlm.nih.gov/pubmed/14978279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307340101
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