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Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring

The function of some multidomain proteins is regulated by interdomain communication. We use second-site suppressor cysteine mutations to test a hypothesis on how the inserted (I)-like domain in the integrin β-subunit regulates ligand binding by the neighboring I domain in the integrin α-subunit [Hut...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Yang, Wei, Shimaoka, Motomu, Salas, Azucena, Takagi, Junichi, Springer, Timothy A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC365718/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14978279/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307340101
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