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Reversibly locking a protein fold in an active conformation with a disulfide bond: Integrin αL I domains with high affinity and antagonist activity in vivo

The integrin αLβ2 has three different domains in its headpiece that have been suggested to either bind ligand or to regulate ligand binding. One of these, the inserted or I domain, has a fold similar to that of small G proteins. The I domain of the αM and α2 subunits has been crystallized in both op...

詳細記述

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書誌詳細
主要な著者: Shimaoka, Motomu, Lu, Chafen, Palframan, Roger T., von Andrian, Ulrich H., McCormack, Alison, Takagi, Junichi, Springer, Timothy A.
フォーマット: Artigo
言語:Inglês
出版事項: The National Academy of Sciences 2001
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC33413/
https://ncbi.nlm.nih.gov/pubmed/11353828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.101130498
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