Stabilizing the integrin αM inserted domain in alternative conformations with a range of engineered disulfide bonds
Conformational movement of the C-terminal α7 helix in the integrin inserted (I) domain, a major ligand-binding domain that adopts an α/β Rossmann fold, has been proposed to allosterically regulate ligand-binding activity. Disulfide bonds were engineered here to reversibly lock the position of the α7...
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| Опубликовано в:: | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2002
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139213/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12466503/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.252633099 |
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