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Stabilizing the integrin αM inserted domain in alternative conformations with a range of engineered disulfide bonds
Conformational movement of the C-terminal α7 helix in the integrin inserted (I) domain, a major ligand-binding domain that adopts an α/β Rossmann fold, has been proposed to allosterically regulate ligand-binding activity. Disulfide bonds were engineered here to reversibly lock the position of the α7...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2002
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC139213/ https://ncbi.nlm.nih.gov/pubmed/12466503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.252633099 |
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