Stabilizing the integrin αM inserted domain in alternative conformations with a range of engineered disulfide bonds

Conformational movement of the C-terminal α7 helix in the integrin inserted (I) domain, a major ligand-binding domain that adopts an α/β Rossmann fold, has been proposed to allosterically regulate ligand-binding activity. Disulfide bonds were engineered here to reversibly lock the position of the α7...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Shimaoka, Motomu, Lu, Chafen, Salas, Azucena, Xiao, Tsan, Takagi, Junichi, Springer, Timothy A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2002
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC139213/
https://ncbi.nlm.nih.gov/pubmed/12466503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.252633099
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller