Reversibly locking a protein fold in an active conformation with a disulfide bond: Integrin αL I domains with high affinity and antagonist activity in vivo

The integrin αLβ2 has three different domains in its headpiece that have been suggested to either bind ligand or to regulate ligand binding. One of these, the inserted or I domain, has a fold similar to that of small G proteins. The I domain of the αM and α2 subunits has been crystallized in both op...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Shimaoka, Motomu, Lu, Chafen, Palframan, Roger T., von Andrian, Ulrich H., McCormack, Alison, Takagi, Junichi, Springer, Timothy A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33413/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11353828/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.101130498
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