The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity

The molecular and structural basis of anesthetic interactions with conformations and functionalities of cell surface receptors remains to be elucidated. We have demonstrated that the widely used volatile anesthetic isoflurane blocks the activation-dependent conformational conversion of integrin lymp...

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Detalhes bibliográficos
Main Authors: Yuki, Koichi, Astrof, Nathan S., Bracken, Clay, Yoo, Ronnie, Silkworth, Whitney, Soriano, Sulpicio G., Shimaoka, Motomu
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2008
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614612/
https://ncbi.nlm.nih.gov/pubmed/18708587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-113324
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