Carregando...
An internal ligand-bound, metastable state of a leukocyte integrin, α(X)β(2)
How is massive conformational change in integrins achieved on a rapid timescale? We report crystal structures of a metastable, putative transition state of integrin α(X)β(2). The α(X)β(2) ectodomain is bent; however, a lattice contact stabilizes its ligand-binding αI domain in a high affinity, open...
Na minha lista:
| Principais autores: | , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2013
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3840939/ https://ncbi.nlm.nih.gov/pubmed/24385486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201308083 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|