An internal ligand-bound, metastable state of a leukocyte integrin, α(X)β(2)

How is massive conformational change in integrins achieved on a rapid timescale? We report crystal structures of a metastable, putative transition state of integrin α(X)β(2). The α(X)β(2) ectodomain is bent; however, a lattice contact stabilizes its ligand-binding αI domain in a high affinity, open...

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Bibliographic Details
Main Authors: Sen, Mehmet, Yuki, Koichi, Springer, Timothy A.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2013
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840939/
https://ncbi.nlm.nih.gov/pubmed/24385486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201308083
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