Ligand- and cation-induced structural alterations of the leukocyte integrin LFA-1

In αI integrins, including leukocyte function–associated antigen 1 (LFA-1), ligand-binding function is delegated to the αI domain, requiring extra steps in the relay of signals that activate ligand binding and coordinate it with cytoplasmic signals. Crystal structures reveal great variation in orien...

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Udgivet i:J Biol Chem
Main Authors: Sen, Mehmet, Koksal, Adem C., Yuki, Koichi, Wang, Jianchuan, Springer, Timothy A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5925802/
https://ncbi.nlm.nih.gov/pubmed/29507098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000710
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