Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration

Integrin αβ heterodimer cell surface receptors mediate adhesive interactions that provide traction for cell migration. Here, we test whether the integrin, when engaged to an extracellular ligand and the cytoskeleton, adopts a specific orientation dictated by the direction of actin flow on the surfac...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Nordenfelt, Pontus, Moore, Travis I., Mehta, Shalin B., Kalappurakkal, Joseph Mathew, Swaminathan, Vinay, Koga, Nobuyasu, Lambert, Talley J., Baker, David, Waters, Jennifer C., Oldenbourg, Rudolf, Tani, Tomomi, Mayor, Satyajit, Waterman, Clare M., Springer, Timothy A.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725580/
https://ncbi.nlm.nih.gov/pubmed/29229906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01848-y
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