Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions

Integrins are transmembrane receptors that, upon activation, bind extracellular ligands and link them to the actin filament (F-actin) cytoskeleton to mediate cell adhesion and migration. Cytoskeletal forces in migrating cells generated by polymerization- or contractility-driven “retrograde flow” of...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Swaminathan, Vinay, Kalappurakkal, Joseph Mathew, Mehta, Shalin B., Nordenfelt, Pontus, Moore, Travis I., Koga, Nobuyasu, Baker, David A., Oldenbourg, Rudolf, Tani, Tomomi, Mayor, Satyajit, Springer, Timothy A., Waterman, Clare M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635867/
https://ncbi.nlm.nih.gov/pubmed/29073038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701136114
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