Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration

Integrin αβ heterodimer cell surface receptors mediate adhesive interactions that provide traction for cell migration. Here, we test whether the integrin, when engaged to an extracellular ligand and the cytoskeleton, adopts a specific orientation dictated by the direction of actin flow on the surfac...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Nordenfelt, Pontus, Moore, Travis I., Mehta, Shalin B., Kalappurakkal, Joseph Mathew, Swaminathan, Vinay, Koga, Nobuyasu, Lambert, Talley J., Baker, David, Waters, Jennifer C., Oldenbourg, Rudolf, Tani, Tomomi, Mayor, Satyajit, Waterman, Clare M., Springer, Timothy A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725580/
https://ncbi.nlm.nih.gov/pubmed/29229906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01848-y
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