An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis

Subcutaneous xenografts have been used for decades to study hepatocellular carcinoma (HCC). These models do not reproduce the specific pathophysiological features of HCCs, which occur in cirrhotic livers that show pronounced necroinflammation, abnormal angiogenesis and extensive fibrosis. As these f...

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Pubblicato in:Nat Protoc
Autori principali: Reiberger, Thomas, Chen, Yunching, Ramjiawan, Rakesh R, Hato, Tai, Fan, Christopher, Samuel, Rekha, Roberge, Sylvie, Huang, Peigen, Lauwers, Gregory Y, Zhu, Andrew X, Bardeesy, Nabeel, Jain, Rakesh K, Duda, Dan G
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4800979/
https://ncbi.nlm.nih.gov/pubmed/26203823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2015.080
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