An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis

Subcutaneous xenografts have been used for decades to study hepatocellular carcinoma (HCC). These models do not reproduce the specific pathophysiological features of HCCs, which occur in cirrhotic livers that show pronounced necroinflammation, abnormal angiogenesis and extensive fibrosis. As these f...

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Detalhes bibliográficos
Publicado no:Nat Protoc
Main Authors: Reiberger, Thomas, Chen, Yunching, Ramjiawan, Rakesh R, Hato, Tai, Fan, Christopher, Samuel, Rekha, Roberge, Sylvie, Huang, Peigen, Lauwers, Gregory Y, Zhu, Andrew X, Bardeesy, Nabeel, Jain, Rakesh K, Duda, Dan G
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4800979/
https://ncbi.nlm.nih.gov/pubmed/26203823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2015.080
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